Effect of alcohol on renal vitamin D metabolism in chickens. |
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Authors: | J C Kent R D Devlin D H Gutteridge R W Retallack |
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Institution: | Endocrinology Unit, Sir Charles Gairdner Hospital, Queen Elizabeth II Medical Centre, Nedlands, 6009, Western Australia Australia |
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Abstract: | Intraperitoneal administration of ethanol to young chickens (both vitamin D-replete and vitamin D-deficient) produced a significant impairment of renal 25 hydroxyvitamin D3 1α-hydroxylase (EC 1.14.13.13) activity with no significant change in serum calcium or phosphorus. In ethanol treated D-replete chicks the renal 25 hydroxyvitamin D3 24-hydroxylase activity was enhanced, and serum 25 hydroxyvitamin D3 was significantly increased. The alkaline phosphatase levels in the D-deficient ethanol treated chicks were significantly less than the controls. Our data suggest that the impairment of the metabolic effects of vitamin D due to ethanol occurs chiefly via a renal, rather than a hepatic mechanism. Furthermore, 1α -hydroxylated metabolites of vitamin D would appear to be the logical treatment of choice for the bone disease of alcoholism. |
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Keywords: | 24-OHase 1α-OHase PTH parathyroid hormone CT calcitonin |
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