Partial characterization of rat hepatoma cell-surface glycopeptides possessing concanavalin A receptor activity. |
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| Authors: | J M Robinson D F Smith E M Davis E B Gilliam S C Capetillo E F Walborg |
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| Affiliation: | 1. Biochemistry Department, The University of Texas System Cancer Center M. D. Anderson Hospital and Tumor Institute Houston Texas 77030 USA.;2. The Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston Texas 77030 USA. |
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| Abstract: | Papain digestion of Novikoff or AS-30D rat hepatoma cells released glycopeptides from the cell surface. That portion of the glycopeptides accessible to Sephadex G-50 was digested with pronase and the component glycopeptides partially resolved by ion-exchange chromatography. Each tumor type yielded two well resolved sialoglycopeptide fractions which possessed concanavalin A receptor activity. The amino acid and saccharide composition of these low molecular weight (3,100 ± 300 daltons) sialoglycopeptides was determined. |
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