电子支气管镜下氩气刀联合冷冻疗法治疗晚期肺癌的临床疗效及对患者癌性疼痛和免疫功能的影响

目的:评价电子支气管镜下氩气刀联合冷冻疗法治疗晚期肺癌的疗效及对患者癌性疼痛和免疫功能的影响。方法:选择我院2016年7月～2018年7月收治的94例晚期肺癌患者,按随机数字表法分为对照组(51例)和4研究组(43例)。对照组采用常规化疗,研究组在对照组基础上联合电子支气管镜下氩气刀和冷冻疗法。治疗后,比较两组的临床疗效,治疗前后疼痛程度、疼痛介质、免疫功能、生活质量的变化和不良反应的发生情况。结果:治疗后,研究组疾病控制率显著高于对照组(P0.05),两组疼痛Ⅰ级率、CD4~+、CD4~+/CD8~+及生活质量评分均较治疗前显著上升(P0.05),而疼痛介质及CD8~+均较治疗前明显下降(P0.05),研究组疼痛Ⅰ级率、CD4~+、CD4+/CD8~+及生活质量评分明显高于对照组,而疼痛介质及CD8~+均显著低于对照组(P0.05)。两组总不良反应发生率比较差异无统计学意义(P0.05)。结论:电子支气管镜下氩气刀联合冷冻疗法用于治疗晚期肺癌的疗效明显优于常规化疗,其可显著减轻癌性疼痛,改善患者免疫功能斌提高患者的生活质量。

Curative Efficacy of Argon Argon Knife Combined with Cryotherapy in the Treatment of Advanced Lung Cancer and Its Effect on the Cancer Pain and Immune Function

ABSTRACT Objective: To evaluate the efficacy of argon gas knife combined with cryotherapy under electronic bronchoscope in the treatment of advanced lung cancer and its effect on the cancer pain and immune function of patients. Methods: 94 patients with advanced lung cancer admitted to our hospital from July 2016 to July 2018 were randomly divided into the control group (51 cases) and the research group (43 cases). The control group was given conventional chemotherapy, while the research group was treated by argon knife and cryotherapy under electronic bronchoscope on the basis of control group. After treatment, the clinical effects, changes of pain degree, pain medium, immune function, quality of life before and after treatment, and incidence of adverse reactions were compared between two groups. Results: After treatment, the disease control rate of research group was significantly higher than that of the control group (P<0.05). the pain grade I rate, CD4⁺, CD4⁺/CD8⁺ and quality of life scores of both groups were significantly higher than those before treatment (P<0.05), while the pain medium and CD8⁺ were significantly lower than those before treatment (P>0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: The therapeutic effect of argon gas knife combined with cryotherapy under electronic bronchoscope in the treatment of advanced lung cancer is obviously superior to the conventional chemotherapy, it can significantly reduce cancer pain, improve the immune function and quality of life of patients.