Brote de histoplasmosis en la provincia de Neuquén,Patagonia Argentina |
| |
Authors: | Liliana María Calanni Rufina Ana Pérez Susana Brasili Norma Graciela Schmidt Cristina Adela Iovannitti María Fernanda Zuiani Ricardo Negroni Jorge Finquelievich Cristina Elena Canteros |
| |
Institution: | 1. Hospital Provincial Neuquén Dr. Eduardo Castro Rendón, Neuquén Capital, Provincia de Neuquén, Argentina;2. Centro de Micología, IMPAM, CONICET-UBA, Facultad de Medicina, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina;3. Departamento de Micología, INEI-ANLIS Dr. Carlos G. Malbrán, Ciudad Autónoma de Buenos Aires, Argentina |
| |
Abstract: | BackgroundIn Argentina, there are no reports of autochthonous cases of histoplasmosis in the southern regions of the country.AimTo report a histoplasmosis outbreak in Zapala town, Province of Neuquén, Patagonia Argentina.MethodsWe evaluated the clinical and epidemiological characteristics of 5 patients involved in the outbreak. Environmental studies were conducted to determine the source of infection. The genetic profile of Histoplasma capsulatum strains isolated from the index case (IC) were compared with clinical isolates from Argentinean patients not related to the outbreak, using RAPD-PCR with primers 1281-1283.ResultsThe patients were residents of Zapala, and had not visited other geographical areas before. All patients had an influenza-like syndrome, and X-ray revealed disseminated micronodular images throughout the lung parenchyma. The IC needed specific antifungal therapy; the remaining 4 patients had mild symptoms, and did not require therapy. All of them had a good clinical outcome. Strains of H. capsulatum isolated from blood culture and lung biopsy of the IC showed a genetic profile different from other strains analyzed. The presence of the fungus in the environment was demonstrated by the detection of anti-Histoplasma antibodies in BALB/c mice inoculated with soil obtained in a culvert where workers had dug up earth after a landslide.ConclusionsThis outbreak suggests the histoplasmosis endemic area is under the 38° S parallel. Patients from Neuquén, Patagonia Argentina, with compatible symptoms of histoplasmosis should be tested, regardless of their travel or exposure history. |
| |
Keywords: | Histoplasmosis Outbreak Argentina RAPD-PCR |
本文献已被 ScienceDirect 等数据库收录! |
|