Boron neutron capture therapy (BNCT) in Finland: Technological and physical prospects after 20 years of experiences |
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| Authors: | Sauli Savolainen Mika Kortesniemi Marjut Timonen Vappu Reijonen Linda Kuusela Jouni Uusi-Simola Eero Salli Hanna Koivunoro Tiina Seppälä Nadja Lönnroth Petteri Välimäki Heini Hyvönen Petri Kotiluoto Tom Serén Antti Kuronen Sami Heikkinen Antti Kosunen Iiro Auterinen |
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| Institution: | 1. Department of Physics, University of Helsinki, Finland;2. HUS Helsinki Medical Imaging Center, Helsinki University Central Hospital, Finland;3. Department of Oncology, Helsinki University Central Hospital, Finland;4. Boneca Corporation, Finland;5. VTT Technical Research Centre of Finland, Finland;6. Department of Chemistry, University of Helsinki, Finland;7. STUK – Radiation and Nuclear Safety Authority, Finland |
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| Abstract: | Boron Neutron Capture Therapy (BNCT) is a binary radiotherapy method developed to treat patients with certain malignant tumours. To date, over 300 treatments have been carried out at the Finnish BNCT facility in various on-going and past clinical trials. In this technical review, we discuss our research work in the field of medical physics to form the groundwork for the Finnish BNCT patient treatments, as well as the possibilities to further develop and optimize the method in the future. Accordingly, the following aspects are described: neutron sources, beam dosimetry, treatment planning, boron imaging and determination, and finally the possibilities to detect the efficacy and effects of BNCT on patients. |
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