| 沙门氏菌抗生素抗性机理研究进展 |
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| 引用本文： | 杨保伟,盛 敏,席美丽,申进玲,孟江洪.沙门氏菌抗生素抗性机理研究进展[J].微生物学通报,2008,35(9):1479-1484. |
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| 作者姓名： | 杨保伟 盛 敏 席美丽 申进玲 孟江洪 |
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| 作者单位： | 1. 西北农林科技大学,食品科学与工程学院,杨凌,712100
2. 西北农林科技大学,生命科学学院,杨凌,712100 |
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| 基金项目： | 西北农林科技大学留学回国人员基金，长江学者讲座教授奖励计划项目 |
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| 摘 要： | 沙门氏菌的多重耐药性问题已经成为世界范围内的公共卫生和经济问题.目前沙门氏菌抗生素抗性机理的研究主要集中以下方面:(1)基因突变与抗生素抗性;(2)外排泵与抗生素抗性:(3)耐药基因编码的钝化酶和灭活酶引起的抗生素抗性;(4)可移动的细菌遗传耐药基因元件及其转移与抗生素抗性.本文基于以上几个方面综述了与沙门氏菌抗生素抗性机理研究相关的研究动态和研究进展.
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| 关 键 词： | 沙门氏菌 基因突变 外排泵 耐药基因 可移动耐药基因元件 抗生素抗性 |
Progress on Studies of Mechanism of Antibiotic Resistance of Salmonella |
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| YANG Bao-Wei,SHENG Min,XI Mei-Li,SHEN Jin-Ling and MENG Jiang-Hong.Progress on Studies of Mechanism of Antibiotic Resistance of Salmonella[J].Microbiology,2008,35(9):1479-1484. |
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| Authors: | YANG Bao-Wei SHENG Min XI Mei-Li SHEN Jin-Ling and MENG Jiang-Hong |
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| Institution: | College of Food Science and Engineering, Northwest A&F University, Yangling 712100;College of Life Science, Northwest A&F University, Yangling 712100;College of Food Science and Engineering, Northwest A&F University, Yangling 712100;College of Food Science and Engineering, Northwest A&F University, Yangling 712100;College of Food Science and Engineering, Northwest A&F University, Yangling 712100 |
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| Abstract: | Multidrug-resistant Salmonella has become a public health and economic problem worldwide. Antibiotic resistance in bacteria can be caused by gene mutation, overexpression of efflux pumps, and mobile genetic elements such as plasmids and integrons that carry genes encoding enzyme(s) that inactivates or modifies antibiotics. This review focuses on research progress related to elucidating mechanism of antibiotic resistance in Salmonella. |
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| Keywords: | Salmonella Gene mutation Efflux pump Antibiotic resistant gene Mobile genetic elements Antibiotic resistance |
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