Interleukin-18: biological properties and clinical implications |
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| Authors: | Lebel-Binay S Berger A Zinzindohoué F Cugnenc P Thiounn N Fridman W H Pagès F |
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| Affiliation: | Luti/Laboratoire de Recherche Chirurgicale, Bat. Gustave-Roussy, 3e étage, H?pital Cochin, 27, rue du Faubourg-St-Jacques, 75014 Paris, France. sophie.lebel-binay@cochin.univ-paris5.fr |
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| Abstract: | IL-18, originally identified as interferon-gamma inducing factor (IGIF), is related to the IL-1 family in terms of its structure, processing, receptor, signal transduction pathway and pro-inflammatory properties. IL-18 is also functionally related to IL-12, as it induces the production of Th1 cytokines and participates in cell-mediated immune cytotoxicity. This review summarizes the recent advances in the understanding of IL-18 structure, processing, receptor expression and immunoregulatory functions, and focuses on the role of IL-18 modulation in tumours, infections, and autoimmune and inflammatory diseases. |
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