Rate and accuracy of bacterial protein synthesis revisited |
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Authors: | Johansson Magnus Lovmar Martin Ehrenberg Måns |
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Institution: | Department of Cell and Molecular Biology, Uppsala University, BMC, Box 596, SE-75124 Uppsala, Sweden. |
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Abstract: | Our understanding of the accuracy of tRNA selection on the messenger RNA programmed ribosome has recently increased dramatically because of high-resolution crystal structures of the ribosome, cryo-electron microscopy reconstructions of its functional complexes, and fast kinetics experiments. Application of single-molecule spectroscopy with fluorescence resonance energy transfer to studies of tRNA selection by the ribosome has also provided new, albeit controversial, insights. Interestingly, when the fundamental trade-off between rate and accuracy in substrate-selective biosynthetic reactions is taken into account, some aspects of the current models of ribosome function appear strikingly suboptimal in the context of growing bacterial cells. |
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