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Synthesis and activity of a novel class of tribasic macrocyclic antibiotics: the triamilides |
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| Authors: | Letavic Michael A Bronk Brian S Bertsche Camilla D Casavant Jeffrey M Cheng Hengmiao Daniel Kirsten L George David M Hayashi Shigeru F Kamicker Barbara J Kolosko Nicole L Norcia Laura J L Oberton Vanessa D Rushing Margaret A Santoro Sheryl L |
| Affiliation: | Pfizer Global Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT 06340, USA. michael_a_letavic@groton.pfizer.com |
| Abstract: | The stereoselective synthesis of two novel series of tribasic macrocyclic antibiotics with potent in vitro activity against Pasteurella multocida and Escherichia coli strains of bacteria is described. The in vitro activity can be significantly influenced by the nature of the substituents on the C-4" aminoalcohol, with the stereochemistry of the C-4" alcohol playing a less critical role. The effect of substitution and stereochemistry on the in vivo activity in a murine model of respiratory infection is also described. |
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