Total synthesis of L-2,2-difluoro-2-deoxy-MYO-inositol 1,4,5-trisphosphate, a potent inhibitor of the enzymes of d-MYO-inositol 1,4,5-trisphosphate metabolism |
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Authors: | Deborah A Sawyer and Barry V L Potter |
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Affiliation: | a Department of Chemistry, University of Leicester, Leicester LE1 7Rh, UK b School of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK |
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Abstract: | The synthesis of the enantiomers of 2,2-difluoro-2-deoxy-myo-inositol 1,4,5-trisphosphate is reported. L-2,2-difluoro-2-deoxy-myo-inositol 1,4,5-trisphosphate is a potent inhibitor of 3-kinase and 5-phosphatase. |
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