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Optimization of enantioselective synthesis of methyl (R)-2-chloromandelate by whole cells of Saccharomyces cerevisiae |
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| Authors: | Min Jeong Yoon Mi Lee Soon Ho Hong Sung Young Park Ik-keun Yoo and Mee Jung Han |
| Institution: | (1) School of Chemical Engineering and Bioengineering, University of Ulsan, 29 Mugeo-dong Nam-gu, Ulsan, 680-749, Republic of Korea;(2) Ulsan Fine Chemical Industry Center, Ulsan Industry Promotion Techno Park, 411, Daun-dong, Jung-gu, Ulsan, 681-340, Republic of Korea;(3) Department of Chemical and Biological Engineering, Chungju National University, 72 Daehak-ro, Chungju-si, Chungbuk, 380-702, Republic of Korea;(4) School of Chemical and Biomolecular Engineering, Dongyang University, 1 Kyochon, Pungki-eup, Youngju-si, 750-711, Republic of Korea; |
| Abstract: | Methyl (R)-2-chloromandelate, a key intermediate in the synthesis of clopidogrel, was obtained by the reduction of methyl-2-chlorobenzoylformate using whole cells of Saccharomyces cerevisiae. A 100% conversion and 96.1% of enantiomeric excess (ee) value was obtained when 17 methyl-2-chlorobenzoylformate/l was reacted with 8 g S. cerevisiae/l and 83 g glucose/l at pH 7. |
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