Lipofuscin |
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| Authors: | Terman Alexei Brunk Ulf T |
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| Affiliation: | 1. Laboratory of Manipulation of Oocytes Enclosed in Preantral Follicles (LAMOFOPA), Faculty, State University of Ceará, Av. Paranjana, 1700, Campus do Itaperi, Fortaleza, CE 60740-000, Brazil;2. Postgraduate Biotechnology, Potiguar University/Laureate International Universities, Av. Senador Salgado Filho, 1610, Lagoa Nova, Natal, CE 59056-000, Brazil;3. Nucleus of Biotechnology Applied to Ovarian Follicle Development, Federal University of San Francisco Valley, Petrolina, PE, Brazil;1. Division of Experimental Vitreoretinal Surgery, Centre for Ophthalmology, University of Tübingen, Schleichstrasse 12/1, 72076 Tübingen, Germany;2. NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany;3. STZ OcuTox Preclinical Drug Assessment, Hechingen, Germany;1. Department of Animal Physiology-II, Faculty of Biological Sciences, Complutense University of Madrid (UCM), E-28040, Spain;2. Department of Basic Biomedical Science, Faculty of Biomedical Science, Universidad Europea, Madrid E-28670, Spain;3. Department of Genetics, Faculty of Biological Sciences, Complutense University of Madrid (UCM), E-28040, Spain;4. Department of Experimental Medicine, Faculty of Medicine, University of Lleida-IRBLLEIDA, Lleida E-25198, Spain |
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| Abstract: | Over time, postmitotic cells accumulate a non-degradable intralysosomal substance, lipofuscin, which forms due to iron-catalyzed oxidation/polymerization of protein and lipid residues. Lipofuscin is often considered a hallmark of aging, showing an accumulation rate that inversely correlates with longevity. There is an emerging impression that lipofuscin, although still typically considered a harmless wear-and-tear product, may have multiple negative effects. By interfering with the important autophagic process, by which most worn out cellular components are degraded, it may prevent cellular renewal and advance the accumulation of damaged cellular constituents. Due to binding of transition metals, such as iron and copper, lipofuscin also seems to sensitize lysosomes and cells to oxidative stress. Of importance for the pathogenesis of age-related macular degeneration, lipofuscin deposition interferes with the phagocytic activity of retinal pigment epithelial cells and also sensitizes their lysosomes to blue light. |
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