Release of (14C)5-hydroxytryptamine from human platelets by red wine |
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| Authors: | J Jarman V Glover M Sandler |
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| Affiliation: | Department of Chemical Pathology, Queen Charlotte's and Chelsea Hospital, London, UK. |
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| Abstract: | Red wine, at a final dilution of 1/50, caused release of [14C]5-hydroxytryptamine (5-HT) from preloaded platelets, an effect which was not observed with any white wines or beers tested. Since 5-HT, is probably released from body stores during migraine attacks and red wine is known to provoke migraine episodes in susceptible individuals, release of 5-HT, possibly from central stores, could represent a plausible mechanism for its mode of action. |
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