On calculation of rate and dissociation constants from kinetic constants for the Ordered Bi Bi mechanism of liver alcohol dehydrogenase |
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| Authors: | B V Plapp |
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| Affiliation: | Department of Biochemistry, College of Medicine, The University of Iowa, Iowa City, Iowa 52242 U.S.A. |
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| Abstract: | Rate and dissociation constants for the Ordered Bi Bi mechanism can be incorrectly calculated if interconversion of central complexes is ignored. The problems are illustrated by an examination of the kinetics of liver alcohol dehydrogenase. Definitions of the kinetic constants in terms of rate constants for the complete mechanism are presented. |
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