4种中草药及其复方抗马拉色菌体的外药敏实验

目的观察苦参、当归、侧柏叶和白鲜皮及观察苦参、当归、侧柏叶和白鲜皮、混合药液与主要有效成分对4株CBS马拉色菌标准株的体外抑菌效果。方法通过液基稀释法，用含橄榄油的液体培养基测定各药液对马拉色菌的抑制作用。结果最小抑菌浓度（MIC）由小到大排列分别为：白鲜碱、苦参碱、苦参、侧柏叶、氧化苦参碱、侧柏叶＋当归（二仙丸）、混合药液（侧柏叶＋当归＋苦参＋白鲜皮）、白鲜皮、二仙丸＋苦参、苦参＋白鲜皮、二仙丸＋白鲜皮、槲皮素、当归、阿魏酸。结论4种中草药及其混合药液、主要有效成分均有抑制马拉色菌的作用。

Inhibitive effect of 4 kinds of Chinese herbal and their compound on Malassezia in vitro

Objective To observe the vitro inhibitive effect of lightyellow Sothora Root, Desefruit Pittany Poot-baik, Cacumen Platycladi, Radix Angelicae Sinensis and their mixture on the CBS standard strains of Malassezia. Methods Liquid medium inclu- ding olive oil was used to test the sensitivity of Chinese herb to Malassezia. Results Minimum Inhibitive sensitivity （MIC） sorted from small to large were Dictamnine, Matrine, lightyellow Sothora Root, Cacumen Platycladi, Oxymatrine, Cacumen Platycladi ＋ Radix Angelicae Sinensis （Immortals pills）, Four Chinese herbal medicine mixture, Desefruit Pittany Poot-baik, Immortals pills ＋ lightyellow Sothora Root, Immortals pills ＋ Desefruit Pittany Poot-baik Root, Quercetin, Radix Angelicae Sinensis and Ferulic acid. Conclusion Four Chinese herbal medicine, their mixture and main active ingredients can inhibit Malassezia.