| 白念珠菌MAPK信号通路研究进展 |
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| 引用本文： | 王德,黄欣,赵力澜,赵敬军. 白念珠菌MAPK信号通路研究进展[J]. 中国真菌学杂志, 2013, 0(4): 252-256 |
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| 作者姓名： | 王德 黄欣 赵力澜 赵敬军 |
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| 作者单位： | 上海市同济医院同济大学附属同济医院皮肤科,上海200065 |
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| 基金项目： | 上海市自然科学基金（13ZR1437900）,国家自然科学基金（81071329） |
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| 摘 要： | 白念珠菌是人类最常见的条件致病菌。促分裂素原活化蛋白激酶（MAPK链）是真核生物信号传递网络中的重要途径之一，在基因表达调控和细胞质功能活动中发挥关键作用。在白念珠菌中主要有4条MAPK途径：Mkcl途径、Cekl途径、Cek2途径和HOG途径。其中HOG途径在白念珠菌MAPK信号通路起着重要的作用。对于白念珠菌MAPK信号通路的作用及相关调控机制的了解，可以为寻找新的药物作用靶点，治疗念珠菌病提供帮助。
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| 关 键 词： | 白念珠菌 MAPK信号通路 Hog途径 |
Advances in the MAPK signaling pathway of Candida albicans |
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| WANG De,HUANG Xin,ZHAO Li-lan,ZHAO Jing-jun. Advances in the MAPK signaling pathway of Candida albicans[J]. Chinese JOurnal of Mycology, 2013, 0(4): 252-256 |
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| Authors: | WANG De HUANG Xin ZHAO Li-lan ZHAO Jing-jun |
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| Affiliation: | ( Department of dermatology, Tongji Hospital, Tongji University School of Medicine, Tongji University, Shanghai 200065, China) |
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| Abstract: | Candida albicans is the most common opportunistic pathogen in humans. Mitogen-activated protein kinase （MAPK） chain is one of the most important ways of eukaryotic signal network and it plays a key role in regulating gene expression in the cyto- plasm functions. There are mainly four MAPK signaling pathways in Candida albicans ： Mkcl, Cekl, Cek2 and HOG. The HOG pathway plays an important role in MAPK signaling pathway of Candida albicans. The understanding about the role of MAPK signa- ling pathway in Candida albicans and related regulatory mechanism will provide help to find new drug targets and the treatment of candidiasis. |
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| Keywords: | Candida albicans MAPK signaling pathway HOG pathway |
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