| 白花鬼针草中多烯炔类成分的分离及其生物活性研究 |
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| 引用本文： | 谢金丹,陈仲康,谢富达,胡娟娟,梁慧君,李倩然,袁捷. 白花鬼针草中多烯炔类成分的分离及其生物活性研究[J]. 热带亚热带植物学报, 2021, 29(2): 216-220 |
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| 作者姓名： | 谢金丹 陈仲康 谢富达 胡娟娟 梁慧君 李倩然 袁捷 |
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| 作者单位： | 广州中医药大学中医药数理工程研究院,广州510006;广州中医药大学中药学院,广州510006;广州中医药大学基础医学院,广州510006;广州中医药大学基础医学院中西医结合研究中心,广州510006 |
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| 基金项目： | 国家自然科学基金项目（81903509）资助 |
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| 摘 要： | 为了解白花鬼针草(Bidens pilosa var.radiata)的化学成分,采用多种色谱技术从其提取物中分离多烯炔类成分,并对其生物活性进行研究.结果表明,从白花鬼针草乙酸乙酯提取部位中分离鉴定出4个多烯炔类化合物,分别为5-acetoxy-2-phenyl-ethinyl-thiophene(1)、1-phen...
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| 关 键 词： | 白花鬼针草 多烯炔 MASA 肝细胞毒性 |
| 收稿时间： | 2020-09-27 |
| 修稿时间： | 2020-10-17 |
Studies on Isolation of Polyacetylenes from Bidens pilosa var. radiata and Their Biological Activities |
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| XIE Jin-dan,CHEN Zhong-kang,XIE Fu-d,HU Juan-juan,LIANG Hui-jun,LI Qian-ran,YUAN Jie. Studies on Isolation of Polyacetylenes from Bidens pilosa var. radiata and Their Biological Activities[J]. Journal of Tropical and Subtropical Botany, 2021, 29(2): 216-220 |
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| Authors: | XIE Jin-dan CHEN Zhong-kang XIE Fu-d HU Juan-juan LIANG Hui-jun LI Qian-ran YUAN Jie |
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| Affiliation: | Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China;School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China;Department of Biochemistry, School of Basic Medical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, China;Research Center of Integrative Medicine, School of Basic Medical Science;Guangzhou University of Chinese Medicine, Guangzhou 510006, China |
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| Abstract: | In order to understand the chemical constituents ofBidens pilosavar. radiate, the four polyacetylenes were isolated from ethyl acetate extract of B. pilosavar. radiate by using multiple column chromatography, and their biological activities were studied. Four polyacetylenes were identified as 5-acetoxy-2-phenylethinyl- thiophene (1), 1-phenylhepta-1,3,5-triyne (2), 5-phenyl-2-(1-propynyl)-thiophene (3), and icthyothereol acetate (4). In vitro activity screening, all these compounds showed moderate anti-MRSA activity, and were not toxic to human liver LO2 cells. The NMR spectroscopic data along with the detailed elucidation of compound 1 was firstly presented, besides, compounds 3 and 4 were isolated from Bidens genus for the first time. |
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| Keywords: | Bidens pilosa var. radiata Polyacetylenes MRSA Hepatotoxicity |
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