Identification and characterization of two polymorphic Ya5 Alu repeats |
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| Institution: | 1. Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, CA 94551, USA;2. Department of Pathology, Department of Biometry and Genetics, Stanley S. Scott Cancer Center, Neuroscience Center of Excellence, Louisiana State University Medical Center, 1901 Perdido Street, New Orleans, LA 70112, USA;3. Department of Biochemistry and Molecular Biology, Neuroscience Center of Excellence, Louisiana State University Medical Center, New Orleans, LA 70112, USA;4. Laboratory of Molecular Genetics, Alton Ochsner Medical Foundation, New Orleans, LA 70121, USA;1. Departamento de Sistemática e Ecologia, Universidade Federal da Paraíba, João Pessoa, Paraíba, Brazil;2. Departamento de Ciências Biológicas, Escola Superior de Agricultura “Luiz de Queiroz”, Universidade de São Paulo, São Paulo, Brazil;3. Instituto Tecnológico Vale, Belém, Pará, Brazil;4. Setor de Vertebrados, Museu de Zoologia da Universidade de São Paulo, São Paulo, Brazil;5. Department of Ecology and Evolutionary Biology, Museum of Zoology, University of Michigan, Ann Arbor, MI, USA;1. Department of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, China;2. Department of Geriatric Medicine, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, China;1. Department of Genetics, Maharshi Dayanand University, Rohtak, Haryana 124001, India;2. Retd. Senior Professor and Head, Department of Gynaecology and Obstetrics, Pt. B.D. Sharma University of Health Sciences, Rohtak 124001, India |
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| Abstract: | Two new polymorphic Alu elements (HS2.25 and HS4.14) belonging to the young (Ya5/8) subfamily of human-specific Alu repeats have been identified. DNA sequence analysis of both Alu repeats revealed that each Alu repeat had a long 3′-oligo-dA-rich tail (41 and 52 nucleotides in length) and a low level of random mutations. HS2.25 and HS4.14 were flanked by short precise direct repeats of 8 and 14 nucleotides in length, respectively. HS2.25 was located on human chromosome 13, and HS4.14 on chromosome 1. Both Alu elements were absent from the orthologous positions within the genomes of non-human primates, and were highly polymorphic in a survey of twelve geographically diverse human groups. |
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