Alterations of phosphatidylinositol signal transduction pathway in hepatic mitochondria following aflatoxin B1 administration |
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Authors: | Pasupathy K Krishna M Bhattacharya R K |
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Affiliation: | Radiation Biology and Biochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India. rbbd@magnum.barc.ernet.in |
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Abstract: | A single dose of aflatoxin B1 (7 mg/kg body wt) to male rats significantly stimulated the turnover of mitochondrial phosphoinositides 1-7 hr following its administration. The elevation of phosphatidylinositol 3,4,5-trisphosphate was most pronounced whose level continued to be moderately high even at 17 hr period. The level of diacylglycerol showed a marked increase from 4 hr till 7 hr after carcinogen treatment, whereas that of inositol 1,4,5-trisphosphate recorded an increase with a maximum at 7 hr followed by a gradual decrease to near normal level at 24 hr period. The activation of phosphatidylinositol cycle together with an activation of PI 3-kinase, whose product PIP3 is known to be involved in apoptosis might contribute to the early step in the manifestation of toxicity and/or carcinogenicity. |
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