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| 番鸭呼肠孤病毒和H9 亚型禽流感病毒共感染对番鸭胸腺免疫抑制作用 | |
| 引用本文： | 林锋强,高春亮,陈少莺,朱小丽,程晓霞,王劭,陈仕龙,蔡羲,李兆龙,马春全,赵佳荣.番鸭呼肠孤病毒和H9 亚型禽流感病毒共感染对番鸭胸腺免疫抑制作用[J].微生物学报,2011,51(10):1407-1412. |
| 作者姓名： | 林锋强 高春亮 陈少莺 朱小丽 程晓霞 王劭 陈仕龙 蔡羲 李兆龙 马春全 赵佳荣 |
| 作者单位： | 1. 福建省农业科学院畜牧兽医研究所,福州350013;福建省畜禽疫病防治工程技术研究中心,福州 350013 2. 福建省农业科学院畜牧兽医研究所,福州,350013 3. 福建省农业科学院畜牧兽医研究所,福州350013<中作者单位十>佛山科技学院生命科学学院,佛山 528231 |
| 基金项目： | 福建省自然科学基金项目(2008J0061);国家自然科学基金(30771620) |
| 摘 要： | 【目的】探讨番鸭呼肠孤病毒(muscovy duck reovirus,MDRV)和H9亚型禽流感病毒(H9 avian influenzavirus,AIV)共感染对番鸭胸腺免疫功能的影响。【方法】8日龄番鸭人工感染MDRV或/和H9 AIV,观察番鸭感染后发生率和死亡率、胸腺形态和显微结构变化,淋巴细胞增殖试验检测胸腺细胞增殖功能,RT-PCR检测MDRV或H9 AIV在番鸭胸腺的分布。【结果】H9 AIV感染后番鸭发病率低,无死亡;不影响胸腺的发育,胸腺病理变化不明显,但能显著抑制胸腺淋巴细胞增殖反应。MDRV单独感染番鸭生长迟缓,发病率80%,死亡率50%;胸腺萎缩,出现局限性坏死灶;对番鸭胸腺细胞增殖反应的有抑制作用,差异显著。共感染组番鸭生长迟缓,发病率90%,死亡率70%;胸腺萎缩,淋巴细胞减少,出现局限性坏死灶;对番鸭胸腺细胞增殖反应的有抑制作用,差异极显著。共感染组在病毒检出时间和检出率上均大于单一病毒感染组。【结论】H9AIV感染对胸腺的免疫抑制作用较弱,MDRV感染后对胸腺的免疫抑制作用较强,MDRV与H9AIV共感染在番鸭免疫反应抑制上有协同作用。 |
| 关 键 词： | 番鸭呼肠孤病毒 H9流感病毒 共感染 胸腺 免疫抑制 |
| 收稿时间： | 2011/3/25 0:00:00 |
| 修稿时间： | 2011/6/22 0:00:00 |
Immunosuppression effect of co-infection with MDRV and H9 AIV on thymus in muscovy ducks |
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| Fengqiang Lin,Chunliang Gao,Shaoying Chen,Xiaoli Zhu,Xiaoxia Cheng,Shao Wang,Shilong Chen,Xi Cai,Zhaolong Li,Chunquan Ma and Jiarong Zhao.Immunosuppression effect of co-infection with MDRV and H9 AIV on thymus in muscovy ducks[J].Acta Microbiologica Sinica,2011,51(10):1407-1412. | |
| Authors: | Fengqiang Lin Chunliang Gao Shaoying Chen Xiaoli Zhu Xiaoxia Cheng Shao Wang Shilong Chen Xi Cai Zhaolong Li Chunquan Ma and Jiarong Zhao |
| Institution: | Fengqiang Lin1,2,Chunliang Gao1,Shaoying Chen1,Xiaoli Zhu1,Xiaoxia Cheng1,Shao Wang1,Shilong Chen1,Xi Cai1,Zhaolong Li1,Chunquan Ma 3,Jiarong Zhao3 1 Institute of Animal Husbandry and Veterinary Medicine,Fujian Academy of Agriculture Sciences,Fuzhou 350013,China 2 Fujian Animal Diseases Control Technology Development Center,China 3 College of life Science,Foshan University,Foshan 528231,China |
| Abstract: | Objective] To study the immunosuppression effect on the thymus of muscovy ducks after infected with muscovy duck reovirus(MDRV) and H9 influenza virus(AIV).Methods] After 8-day-old birds were infected with MDRV or H9 AIV,or both,the morbidity and mortality were totaled,the morphology and ultra-structure of the thymus were observed,proliferation ability of thymus cell were detected and the virus distrubition were detected by RT-PCR.Results] After H9 AIV infection,The morbidity was low(10%) and without dea... |
| Keywords: | Muscovy duck reovirus(MDRV) H9 AIV co-infection thymus immunosuppression |
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