Rapid transesterification of bilirubin glucuronides in methanol |
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Authors: | M Salmon C Fenselau J O Cukier G B Odell |
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Institution: | Department of Pharmacology and Experimental Therapeutics, USA;Department of Pediatrics The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA |
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Abstract: | The current studies present evidence that bilirubin conjugates derived from rat bile undergo rapid transesterification, , in solutions containing methanol. The conjugates of bilirubin and the methyl esters formed from them by exposure to methanol were isolated by thin layer chromatography. The isolates were chemically quantitated for their bilirubin and glucuronic acid composition. Characterization of the bilirubin methyl esters was performed by mass spectrometric analysis of the trimethylsilyl and phenylazo derivatives. |
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