ACE I/D gene polymorphism can't predict the steroid responsiveness in Asian children with idiopathic nephrotic syndrome: a meta-analysis |
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Authors: | Zhou Tian-Biao Qin Yuan-Han Su Li-Na Lei Feng-Ying Huang Wei-Fang Zhao Yan-Jun |
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Institution: | Department of Pediatrics, The First Affiliated Hospital of GuangXi Medical University, NanNing, China. |
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Abstract: | BackgroundThe results from the published studies on the association between
angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene
polymorphism and the treatment response to steroid in Asian children with
idiopathic nephrotic syndrome (INS) is still conflicting. This meta-analysis
was performed to evaluate the relation between ACE I/D gene polymorphism and
treatment response to steroid in Asian children and to explore whether ACE D
allele or DD genotype could become a predictive marker for steroid
responsiveness.Methodology/Principal FindingsAssociation studies were identified from the databases of PubMed, Embase,
Cochrane Library and CBM-disc (China Biological Medicine Database) as of
September 1, 2010, and eligible investigations were synthesized using
meta-analysis method. Five investigations were identified for the analysis
of association between ACE I/D gene polymorphism and steroid-resistant
nephrotic syndrome (SRNS) risk in Asian children and seven studies were
included to explore the relationship between ACE I/D gene polymorphism and
steroid-sensitive nephrotic syndrome (SSNS) susceptibility. Five
investigations were recruited to explore the difference of ACE I/D gene
distribution between SRNS and SSNS. There was no a markedly association
between D allele or DD genotype and SRNS susceptibility or SSNS risk, and
the gene distribution differences of ACE between SRNS and SSNS were not
statistically significant. II genotype might play a positive role against
SRNS onset but not for SSNS (OR = 0.51,
P = 0.02;
OR = 0.95,
P = 0.85; respectively), however, the
result for the association of II genotype with SRNS risk was not stable.Conclusions/SignificanceOur results indicate that D allele or DD homozygous can''t become a
significant genetic molecular marker to predict the treatment response to
steroid in Asian children with INS. |
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