胰岛素对中枢神经系统疾病的影响

越来越多的实验证据和临床资料表明,胰岛素在中枢神经系统中发挥重要作用。多种动物脑内有高水平的胰岛素,而且神经元和胶质细胞上均存在胰岛素受体和胰岛素第二信使系统。很多神经性疾病的发病机制都和胰岛素水平或胰岛素敏感性有关。同样,胰岛素样生长因子对神经元功能也有一定的调节作用。胰岛素和包括胰岛素样生长因子在内的多种神经营养因子,在治疗神经退行性疾病方面被人类寄予了厚望。

Effects of insulin on the diseases of central nervous system

There are increasing experimental evidence and clinical data showing that insulin plays an important role in the CNS. Insulin can be found at high level in the brain of some animals. Insulin receptors and insulin second messengers systems are present in neurons and glial cells. The pathogenesis of some neurological diseases is related with insulin level or insulin sensitivity. Insulin like growth factors also have a modulatory role in neuronal function. Insulin and neurotrophic factors including insulin like factors have generated considerable excitement for their potential as therapy for a wide variety of degenerative neurological disorders, for which there is currently no treatment.