The crucial role of hypoxia in halothane-induced lipid peroxidation |
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Authors: | H de Groot T Noll |
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Affiliation: | Institut für Physiologische Chemie I der Universität Düsseldorf Moorenstraße 5, D-4000 Düsseldorf, F.R.G. |
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Abstract: | Halothane-induced lipid peroxidation in NADPH-reduced liver microsomes from phenobarbital-pretreated male rats was studied under defined steady state oxygen partial pressures (Po2). Under anaerobic conditions, as well as at a Po2 above 10 mm Hg no halothane-induced formation of malondialdehyde was detected. At a Po2 below 10 mm Hg, however, with a maximum near 1 mm Hg oxygen, significant halothane-induced malondialdehyde formation was found. This evidence supports the hypothesis that halothane can induce lipid peroxidation. The Po2 (i) must be low enough to permit the reductive formation of . CF3 CHCl-radicals but (ii), it must be high enough to promote formation of lipid peroxides. |
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