Effects of histamine and its derivatives on the excitability of a giant identifiable neuron of Achatina fulica Férussac. A histaminergic receptor different from H1 and H2]

A giant neurone of Achatina fulica Férussac (the TAN, tonically autoactive neurone) is excited by histamine. Pharmacological characteristics of its histaminergic reception are quite different from those of H1 and H2 receptors. The effect of histamine on the TAN is antagonized by neither mepyramine nor burimamide.