| 特比萘芬对24株黑酵母样真菌的体外药敏试验研究 |
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| 引用本文： | 谈鑫,邓淑文,郭芸,张超,朱双,潘炜华,邓丹琪,廖万清.特比萘芬对24株黑酵母样真菌的体外药敏试验研究[J].中国真菌学杂志,2014,9(4):218-221. |
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| 作者姓名： | 谈鑫 邓淑文 郭芸 张超 朱双 潘炜华 邓丹琪 廖万清 |
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| 作者单位： | 1. 昆明医科大学第二附属医院皮肤科,昆明,650101
2. 上海长征医院皮肤病与真菌病研究所上海市医学真菌重点分子生物学实验室,上海,200003 |
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| 基金项目： | 国家973项目，国家科技重大传染病专项，云南省联合专项重点项目，上海市科委专项 |
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| 摘 要： | 目的 评价特比萘芬对7个属24株刺盾霉目（Chaetothyriales）黑酵母样真菌体外敏感性.方法 应用美国国家临床和实验室标准研究所（CLSI）的M38-A2方案.菌悬液终浓度为（0.4 ～5）＆#215;104 CFU/mL,30℃孵育5～7d,测定最低有效浓度（MEC）和最低抑菌浓度（MIC）.结果 特比萘芬对24株黑酵母样真菌MEC范围：0.125 ～4μg/mL,MEC90∶2μg/mL,MEC50∶0.25 μg/mL,GM∶0.392 9 μg/mL,特比萘芬对5株暗色真菌100％生长抑制,MIC范围：1～4 μg/mL,MIC50∶2μg/mL,MIC90∶4μg/mL.结论 特比萘芬对刺盾霉目（Chaetothyriales）中的黑酵母样真菌有较强的抑制作用,50％抑菌作用明显.
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| 关 键 词： | 黑酵母样真菌 药敏试验 特比萘芬 |
In vitro antifungal susceptibility of terbinafine against 24 strains of black yeast like fungi |
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| Institution: | TAN Xin , DENG Shu-wen, GUO Yun , ZHANG Chao, ZHU Shuang , PAN Wei-hua , DENG Dan-qiI, LIAO Wan-qing.( 1. Departmant of Dermatology,Second aflicated hospital of Kunming medical university,Kunming 650101, China ;2. Shanghai Institute of Medical Mycology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China) |
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| Abstract: | Objective To investigate the in vitro susceptibility testing of terbinafine against 24 strains of Black yeast like fungi. Methods CLSI M38-A2 guideline was applied. The media containing the fungi in the concentration of O. 5 ×10^4-4×10^4 CFU/mL were incubated at 30 for 5-7 days. The MIC and MEC values were observed. Results The tested 24 strain of black yeast like fungi were susceptible to terbinafine, MEC range ：0. 125 Ixg/mL-4 txg/mL, MECgo ：2μg/mL, MEC5o ：0.25μg/mL, GM ：0. 392 9μg/mL, Five strains had 100% growth inhibition,MIC range：l-4 μg/mL, MIC5o ：2μg/mL;MICgo ：4 μg/mL. Conclusion Terbinafine is ac- tive aganist black yeast like fungi in order Chaetothyriales. Most strains had MEC which 50% growth inhibition by terbinafine. |
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| Keywords: | black yeast antifungal susceptibility tests terbinafine |
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