Quality control in self/nonself discrimination |
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Authors: | Boehm Thomas |
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Affiliation: | Department of Developmental Immunology, Max-Planck Institute of Immunobiology, Freiburg, Germany. boehm@immunbio.mpg.de |
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Abstract: | Unicellular eukaryotes primarily employ self/nonself discrimination to avoid self-mating, whereas multicellular organisms also use self/nonself discrimination in immune defense. Recent advances in understanding self/nonself discrimination in eukaryotes shed new light on the emergence of the most sophisticated self/nonself discrimination system known, the antigen receptors employed in the adaptive immune system. |
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