Studies on the methylation status of CpG sequences located in promoters of selected tumour suppressor genes in breast cancer cells |
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Authors: | Fabianowska-Majewska K Kordek R Krawczyk B |
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Affiliation: | Department of Biomedicinal Chemistry, Medical University of Lodz, Lodz, Poland. fabian@csk.umed.lodz.pl |
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Abstract: | In the tested samples of sporadic breast cancer (100 cases), hypermethylation of CpG sequences located in ERalpha promoter was observed in 62 cases. It correlated with: (i) deficiency of ERalpha protein in 45%, (ii) hypermethylation of BRCA1 promoter in 95%, and (iii) nonmethylated E-cadherin promoter in 90%. Fifty-eight percent of the patients with nonmethylated E-cadherin promoter (56 cases) did not show metastasis to lymphatic nodes. The analysis of the methylation level of the promoter of ERalpha, BRCA1, and E-cadherin, frequently connected with their activity, shows that it can be an important parameter in the diagnosis and therapeutic strategies in sporadic breast cancer. |
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