Synthesis, characterization, cytotoxicity and antibacterial studies of chitosan, O-carboxymethyl and N,O-carboxymethyl chitosan nanoparticles |
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Authors: | A. Anitha V.V. Divya Rani R. Krishna V. Sreeja N. Selvamurugan S.V. Nair H. Tamura R. Jayakumar |
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Affiliation: | aAmrita Centre for Nanoscience, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Kochi 682026, India;bFaculty of Chemistry, Materials and Bioengineering & High Technology Research Centre, Kansai University, Osaka 564-8680, Japan |
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Abstract: | Chitosan (CS) is a naturally occurring biopolymer. It has important biological properties such as biocompatibility, antifungal and antibacterial activity, wound healing ability, anticancerous property, anticholesteremic properties, and immunoenhancing effect. Recently, CS nanoparticles have been used for biomedical applications. However, due to the limited solubility of CS in water its water-soluble derivatives are preferred for the above said applications. In this work, the nanoparticles of CS and its water-soluble derivatives such as O-carboxymethyl chitosan (O-CMC) and N,O-carboxymethyl chitosan (N,O-CMC) was synthesized and characterized. In addition, cytotoxicity and antibacterial activity of the prepared nanoparticles was also evaluated for biomedical applications. |
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Keywords: | Chitosan nanoparticles Carboxymethyl derivatives Cytotoxicity Antibacterial Biomaterials |
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