Novel metal sites in protein structures |
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| Authors: | Anne Volbeda Juan Carlos Fontecilla-Camps Michel Frey |
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| Affiliation: | Laboratoire de Cristallographie et de Cristallogénèse des Protéines, Institut de Biologie Structurale J P Ebel (CEA, CNRS), 41 avenue des Martyrs, 38027 Grenoble Cedex 1, France |
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| Abstract: | Recently, the three-dimensional structures of several novel metalloenzymes have been solved. Of special interest are those containing uncommon and/or not well characterized metals such as molybdenum, tungsten, nickel, vanadium and cobalt. Modulated by the protein environment, the specific properties of these metals and of special metal-binding cofactors such as siroheme and topa quinone are used to catalyze a vast array of fascinating reactions. |
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| Keywords: | Abbreviations: CO carbon monoxide CoA coenzyme A CODH CO dehydrogenase DMB dimethylbenzylimidazole DMSO dimethyl sulfoxide IR infrared MPT molybdopterin PDB protein data bank TPQ topa (2,4,5-trihydroxyphenylalanine) quinone |
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