Selection of biologically active peptides by phage display of random peptide libraries |
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Authors: | Riccardo Cortese,Paolo Monaci,Alessandra Luzzago,Claudia Santini,Fabrizia Bartoli,Irene Cortese,Paola Fortugno,Giovanni Galfrè ,Alfredo Nicosia,Franco Felici |
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Affiliation: | aIstituto di Ricerche di Biologia Molecolare P. Angeletti, Via Pontina km 30.600, 00040 Pomezia Roma, Italy;bClinica Neurologica, Università di Roma ‘Tor Vergata’ and Clinica S. Lucia, Via Ardeatina 306, 00179 Roma, Italy |
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Abstract: | Random peptide libraries displayed on phage are used as a source of peptides for epitope mapping, for the identification of critical amino acids responsible for protein—protein interactions and as leads for the discovery of new therapeutics. Efficient and simple procedures have been devised to select peptides binding to purified proteins, to monoclonal and polyclonal antibodies and to cell surfaces in vivo and in vitro. |
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Keywords: | Abbreviations: Cryoll type II mixed cryoglobulinemia CSF cerebrospinal fluid EPO erythropoietin EPOr erythropoietin receptor HCV hepatitis C virus MS multiple sclerosis RPL random peptide library SH3 Src homology 3 |
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