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| 黄连-姜黄水煎剂治疗豚鼠皮肤真菌感染 | |
| 引用本文： | 杨明霞,杨维玲,孙彤,于智明,孙丽梅,田静. 黄连-姜黄水煎剂治疗豚鼠皮肤真菌感染[J]. 中国实验动物学报, 2008, 16(6) |
| 作者姓名： | 杨明霞 杨维玲 孙彤 于智明 孙丽梅 田静 |
| 作者单位： | 1. 哈尔滨医科大学附属第一医院皮肤科,哈尔滨,150001 2. 第二炮兵总医院皮肤科,北京,100088 3. 沈阳市第七人民医院皮肤科,沈阳,110003 |
| 摘 要： | 目的 建立石膏样毛癣菌感染皮损豚鼠动物模型并观察黄连-姜黄复方水煎剂的疗效.方法 于32只豚鼠背部建立石膏样毛癣菌感染皮损128处,分四组:(A)100%浓度复方水煎剂治疗组;(B)200%浓度复方水煎剂治疗组;(C)2%硝酸咪康唑软膏治疗组;(D)空白对照组.于感染第4天开始用药,分别于用药第0、3、7、10天做真菌镜检、培养并测量皮损直径.结果 A、B、C组治疗效果均明显好于D组(P<0.01),2%硝酸咪康唑软膏及复方水煎剂均对皮肤石膏样毛癣菌有治疗作用;B、C组治疗效果明显好于A组(P<0.01);B组治疗效果好于C组(P<0.05),治疗过程中无一例出现皮肤刺激症状.结论 黄连一姜黄复方水煎剂对皮肤石膏样毛癣菌有明显治疗作用,无刺激性,具有临床应用前景. |
| 关 键 词： | 黄连 姜黄 石膏样毛癣菌 豚鼠 |
Treatment of Trichophyton Gypseum Skin Infection in Guinea-Pig with Golden Thread and Curcumae Longae Water Apozema |
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| YANG Ming-xia,YANG Wei-ling,SUN Tong,YU Zhi-ming,SUN Li-mei,TIAN Jing. Treatment of Trichophyton Gypseum Skin Infection in Guinea-Pig with Golden Thread and Curcumae Longae Water Apozema[J]. Acta Laboratorium Animalis Scientia Sinica, 2008, 16(6) | |
| Authors: | YANG Ming-xia YANG Wei-ling SUN Tong YU Zhi-ming SUN Li-mei TIAN Jing |
| Affiliation: | YANG Ming-xia~1,YANG Wei-ling~2,SUN Tong~1,YU Zhi-ming~1,SUN Li-mei~1,TIAN Jing~1(1.Department of Dermatology,The First Hospital of Harbin Medical Unversity,Harbin 150001,China,2.Department of Dermatology,General Hospital of the Second Artillery,Beijing 100084,3.Department of Dermatology,Shenyang 7th People's Hospital,Shenyang 110003,China) |
| Abstract: | Objective To establish a model of trichophyton gypseum skin infection in guinea-pig and to observe the therapeutic effect of golden thread-curcumae longae complex water apozema.Methods 128 sites on the skin infected with trichophyton gypseum were established in 32 guinea-pigs.The animals were divided into four groups:(A)treated with 100% concentration of complex water apozema group;(B)treated with 200% concentration of complex water apozema group;(C)treated with 2% miconazole nitrate cream group;(D)the bla... |
| Keywords: | Golden thread Curcumae longae Trichophyton gypseum infection Skin Guinea-pig |
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