Study by NMR and circular dichroism of synthetic "zinc finger" peptide of viral Gag protein from HIV-2 |
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| Authors: | J P Laussac M T Cung M Erard H Mazarguil |
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| Institution: | Laboratoire de Chimie de Coordination du C.N.R.S., Toulouse. |
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| Abstract: | We report the synthesis in solid phase of an 18-amino acid peptide that contains the cysteine-rich region of the structural Gag protein of HIV-2. The characterization of this fragment and of its interaction with Zn2+ has been made by one- (1 D) and two-dimensional (2D) NMR techniques and by circular dichroism. Our results suggest that in aqueous solution the complexation produces a significant perturbation in the conformation of this peptide. |
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