Tailor-made glycoproteins |
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Authors: | Hsieh-Wilson Linda C |
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Affiliation: | Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA. lhw@caltech.edu |
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Abstract: | Posttranslational modifications are a fundamental mechanism for the regulation of cellular physiology and function. A recent paper by Zhang et al. provides a novel strategy for the generation of homogeneous glycoproteins. The ability to install covalent modifications site-specifically into proteins holds tremendous promise for deciphering the role of posttranslational modifications and has exciting implications for the development of protein therapeutics. |
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