Hepatitis B in China: from Guideline to Practice |
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基金项目: | 国家高技术研究发展计划(863计划) |
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摘 要: |
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关 键 词: | 肝炎 中国 患者 健康 医疗状况 |
收稿时间: | 22 February 2008 |
修稿时间: | 2 March 2008 |
Hepatitis B in China: from guideline to practice |
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Authors: | Ji-dong Jia |
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Institution: | Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China |
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Abstract: | Chronic hepatitis B infection is a very important health problem in China, which is carrying an enormous economic and social burdens. The major routs of chronic hepatitis B infection in China are mother-infant vertical transmission and early childhood horizontal transmission. After more than 10 years implementation of universal vaccination against hepatitis B in newborns and safety injection in health care settings, the prevalence of HBsAg in general population has decreased from 9.75% to around 7%. In China, patients with hepatitis are cared by either hepatologists or physicians of infectious diseases. The Chinese Society of Hepatology, and Chinese Society of Infectious Diseases jointly issued an evidence-based guideline on the prevention and treatment of chronic hepatitis B in 2005. This guideline concisely describes the virology, epidemiology, natural history and prevention, as well as diagnosis and management of chronic hepatitis B. It also highlights the importance of active viral replication in disease progression in chronic HBV infection and explicitly states the necessity of antiviral therapy in patient care. The cornerstone of anti-hepatitis B therapy is optimal use of interferons or nucleos(t)ide analogs in those patients with active viral replication and elevated serum transaminase levels. Through an independent continue medical educational agency, a panel of selected speakers were trained to give well-formatted talks on the key points of the guideline in over 60 major cities across China. This educational campaign among health care providers has greatly improved the awareness and the stand of care for antiviral therapy. |
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Keywords: | Hepatitis B China Epidemiology Prevention Treatment |
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