E5 and E6/E7 of high-risk HPVs cooperate to enhance cancer progression through EMT initiation |
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| Authors: | Ala-Eddin Al Moustafa |
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| Institution: | 1College of Medicine & Biomedical Research Center; Qatar University; Doha, Qatar;2Oncology Department; McGill University; Montreal, Canada;3Department of Mechanical Engineering; Concordia University; Montreal, Canada;4Syrian Research Cancer Center of the Syrian Society against Cancer; Aleppo, Syria |
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| Abstract: | It is estimated that 10–20% of human carcinogenesis is linked to virus infection including papillomaviruses (HPVs). Moreover, since metastatic cancer disease is a major cause of morbidity and mortality in cancer patients, the role of onco-viruses in cancer progression to a metastatic form is of particular interest. Recent studies reported that E5 and E6/E7 onco-proteins of high-risk HPVs could enhance cancer progression via the initiation of the epithelial–mesenchymal transition (EMT) event. Herein, we discuss the association between E5 as well as E6/E7 of high-risk HPV and cancer progression. |
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| Keywords: | cancer progression E5 E6/E7 gene cooperation high-risk HPV |
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