Babesia gibsoni: identification of an immunodominant, interspersed repeat antigen |
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| Authors: | Jia Honglin Terkawi M Alaa Aboge Gabriel Oluga Goo Youn-Kyoung Zhou Jinlin Lee Eung-Goo Nishikawa Yoshifumi Igarashi Ikuo Fujisaki Kozo Xuan Xuenan |
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| Institution: | National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan. |
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| Abstract: | In this report, an immunodominant antigen called BgIRA from Babesia gibsoni is identified and described. A highly repetitive antigen was screened from a cDNA library. The genomic BgIRA gene exists as single cope gene and contains 10 introns. BgIRA plays a dominant role in the immune response in dogs infected with B. gibsoni. The specificity and sensitivity of the rBgIRA in an ELISA indicated that this antigen might be useful in a diagnostic test. |
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| Keywords: | BgIRA Babesia gibsoni ELISA |
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