New polyazamacrocycle-nucleoside conjugates: synthesis, anti-HIV evaluation and interaction with CXCR-4 coreceptor. |
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| Authors: | J Dessolin P Galéa P Vlieghe J C Chermann J L Kraus |
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| Institution: | Laboratoire de Chimie Biomoléculaire, Faculté des Sciences de Luminy, Université de la Méditerranée, Marseille, France. |
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| Abstract: | We report the synthesis of new conjugates that incorporate in their structure bis-tetraazamacrocycle coupled with AZT via enzymolabile bond. Two series of bis-polyazamacrocycles-AZT conjugates were designed, synthesized and evaluated for their antiviral effect in vitro as well as their capability to bind to CXCR-4 coreceptor. |
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