A novel neuroprotectant PAN-811 protects neurons from oxidative stress |
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| Authors: | Weiying Pan Chanteé M Dancik Valery M Nelson Zhi-Gang Jiang Michael S Lebowitz Hossein A Ghanbari |
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| Institution: | (1) Johns Hopkins University School of Medicine, MD 21205 Baltimore, USA;(2) GeneDx, MD 20877 Gaithersburg, USA;(3) Panacea Pharmaceuticals, Inc., MD 20877 Gaithersburg, USA |
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| Abstract: | Hydrogen peroxide (H2O2), a major non-radical reactive oxygen species (ROS) could elicit intracellular oxidative damage and/or cause extracellular
free calcium influx by activating the NMDA receptor or through calcium channels. In the present study, NMDA receptor antagonist
MK-801 fully blocked H2O2-induced neuronal cell death, whereas green tea (GT) extract containing-antioxidants only partially suppressed the neurotoxicity
of H2O2. These suggest that majority of ROS overproduction is downstream of H2O2-induced calcium influx. A novel neuroprotectant PAN-811 was previously demonstrated to efficiently attenuate ischemic neurotoxicity.
PAN-811 hereby fully blocks H2O2-elicited neuronal cell death with a more advanced neuroprotective profile than that of GT extract. PAN-811 was also shown
to protect against CaCl2-elicited neurotoxicity. Efficient protection against oxidative stress-induced neurotoxicity by PAN-811 indicates its potential
application in treatment of ROS-mediated neurodegenerative diseases.
W.P. and C.M.D. had equal contributions to this project |
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| Keywords: | PAN-811 Hydrogen peroxide Neuroprotection Chelation Antioxidant |
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