Fine needle aspiration (FNA)-induced necrosis of tumours of the thyroid |
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Authors: | U RAMP P PFITZER H E GABBERT |
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Institution: | Institute of Pathology, University Hospital, Düsseldorf, Germany;Cytopathology, University Hospital, Düsseldorf, Germany |
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Abstract: | Two cases of necrosis of thyroid oxyphilic tumours following FNA are reported. the first patient received surgery 4 weeks after FNA and histological examination revealed an encapsulated and totally necrotic tumour 2 cm in diameter. In the second patient surgery was performed after 25 days. Histological examination showed a 0.7 cm diameter tumour consisting mainly of fibrous tissue with residual oxyphilic tumour cells only in a small peripheral rim. In both patients no capsular or vascular invasion and no blood vessel thrombosis were present. A review of the literature revealed that oxyphilic tumours are susceptible to post-FNA necrosis, which might be due to the compromised vascular supply after FNA in conjunction with the intrinsic energy deficiency of oncocytic tumour cells. |
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Keywords: | so called Hürthle cell tumour FNA-induced necrosis thyroid gland |
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