| 哺乳动物铁稳态分子机制研究进展 |
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| 引用本文： | 张玉超,沈媛媛,晏向华,王福俤. 哺乳动物铁稳态分子机制研究进展[J]. 细胞生物学杂志, 2011, 0(11) |
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| 作者姓名： | 张玉超 沈媛媛 晏向华 王福俤 |
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| 作者单位： | 中国科学院上海生命科学研究院营养科学研究所;华中农业大学动物科技学院; |
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| 基金项目： | 国家重点基础研究发展计划(No.2009CB941400,No.2011CB966200); 国家自然科学基金项目(No.1097907,No.30970665,No.10JC1416800,No.81000358); 中国科学院百人计划(No.KSCX2-YW-R-141); 上海市科委项目(No.10JC1416800); 中国博士后科学基金(No.20100480637)资助项目~~ |
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| 摘 要： | 铁是机体必需微量元素,参与机体合成血红蛋白、肌红蛋白及多种酶的组成和功能发挥,对维持生命和健康至关重要。近四分之一的世界人口遭受铁缺乏或缺铁性贫血的威胁。此外,部分人群还存在铁过载问题,以脏器铁离子蓄积为主要病理改变的遗传性血色病,其在欧美发病率高达1/200,在中国也有报道。血色病后期多诱发肝脏、胰腺及心脏的功能衰退。铁过少或过多对健康都会造成严重危害,机体需要复杂而精密的调控体系维持铁稳态平衡。铁代谢主要包括小肠吸收、肝脏储存、血液转运、巨噬细胞再循环以及周身细胞利用。过去十多年是铁代谢研究的黄金时期,先后发现众多铁稳态代谢相关基因。该文综述了近年来哺乳动物铁代谢领域的研究进展,并对铁稳态代谢中存在的问题进行了初步讨论,为理解和进一步深入研究铁代谢分子机制提供参考。
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| 关 键 词： | 铁 铁稳态 贫血 血色病 |
Molecular Mechanisms of Mammalian Iron Homeostasis |
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| Zhang Yuchao,Shen Yuanyuan,Yan Xianghua,Wang Fudi. Molecular Mechanisms of Mammalian Iron Homeostasis[J]. Chinese Journal of Cell Biology, 2011, 0(11) |
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| Authors: | Zhang Yuchao Shen Yuanyuan Yan Xianghua Wang Fudi |
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| Affiliation: | Zhang Yuchao~(1,2),Shen Yuanyuan~1,Yan Xianghua~2,Wang Fudi~(1*) (1 Institute for Nutritional Science,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 20003,China,2 College of Animal Sciences and Technology,Huazhong Agricultural University,Wuhan 430070,China) |
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| Abstract: | Trace element iron is essential for nearly all living organisms.It is the key component of ironcontaining enzymes and proteins,which participate in many cellular biological processes.It is estimated that nearly one quarter of population worldwide has been suffered from anemia due to iron deficiency.In contrast,iron overload induces a disease termed as Hemochromatosis,which the incidence is approximately 1/200 in Caucasians. Recently,the disease has also been reported in China.It is fatal if the disease prog... |
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| Keywords: | iron iron homeostasis anemia hemochromatosis |
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