| Ridaifen-G诱导细胞死亡不依赖于细胞凋亡蛋白酶(英文) |
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| 引用本文： | 安里菲热·安尼瓦尔,羽鸟麻奈美,森田明典,椎名勇,中田健也,户崎雄太,王艳雯,池北雅彦,李冠.Ridaifen-G诱导细胞死亡不依赖于细胞凋亡蛋白酶(英文)[J].细胞生物学杂志,2011(6). |
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| 作者姓名： | 安里菲热·安尼瓦尔 羽鸟麻奈美 森田明典 椎名勇 中田健也 户崎雄太 王艳雯 池北雅彦 李冠 |
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| 作者单位： | 新疆大学生命科学与技术学院;东京理科大学理工学部应用生物科学科;东京理科大学理学部应用化学科; |
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| 摘 要： | 通过对Ridaifen-G(RID-G)诱导造血细胞U937、Raji、THP-1和IM-9死亡是否需要Z-VAD-fmk(一种细胞凋亡蛋白酶抑制剂)的研究,发现RID-G以细胞凋亡蛋白酶非依存性的方式诱导细胞死亡,并伴随有线粒体功能紊乱。Z-VAD-fmk对U937细胞的死亡没有影响,但抑制etoposide诱导的细胞凋亡;DNA片段化结果表明,RID-G可破坏Raji和THP-1细胞的DNA,经RID-G处理后的U937细胞的DNA条带没有经etoposide处理的清晰。此外,Z-VAD-fmk对U937、THP-1和Raji细胞DNA的片段化程度有不同的影响,抑制细胞死亡。这些结果表明,RID-G诱导的非典型细胞死亡不依赖于caspase,且伴随有线粒体功能紊乱。
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| 关 键 词： | 细胞死亡 线粒体 细胞凋亡蛋白酶 细胞凋亡 Ridaifen-G |
Ridaifen-G Induces Caspase-independent Atypical Cell Death |
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| Anniwaer Anlifeire,Manami Hatori,Akinori Morita,Isamu Shiina,Kenya Nakata,Yu-Ta Tosaki,Yan-Wen Wang,Masahiko Ikekita,Guan Li.Ridaifen-G Induces Caspase-independent Atypical Cell Death[J].Chinese Journal of Cell Biology,2011(6). |
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| Authors: | Anniwaer Anlifeire Manami Hatori Akinori Morita Isamu Shiina Kenya Nakata Yu-Ta Tosaki Yan-Wen Wang Masahiko Ikekita Guan Li |
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| Institution: | Anniwaer Anlifeire~(1,2),Manami Hatori~2,Akinori Morita~2,Isamu Shiina~3,Kenya Nakata~3,Yu-Ta Tosaki~3,Yan-Wen Wang~3,Masahiko Ikekita~2,Guan Li~(1*) (1 College of Life Science,Xinjiang University,Urumqi 830046,China,2 Department of Applied Biological Science,Faculty of Science and Technology,Chiba-ken 278-8510,Japan,3 Department of Applied Chemistry,Faculty of Science,Tokyo University of Science,Tokyo 162-8601,Japan) |
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| Abstract: | We have investigated antitumor activities of Ridaifens(RIDs),which are a series of synthesized Tamoxifen(TAM) derivatives.In this study,we focused on one of RIDs,Ridaifen-G(RID-G),and investigated the cell death-inducing activity of it in four neoplastic hematopoietic cell lines,U937,Raji,THP-1,and IM-9 cells in the presence or absence of a pan-caspase inhibitor,Z-VAD-fmk.The aim of this study is to characterize the mode of RID-G-induced cell death,as compared with a typical apoptosis of etoposide-treated U... |
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| Keywords: | cell death mitochondria caspase apoptosis Ridaifen-G |
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