| 组蛋白脱乙酰酶抑制剂的抗癌作用 |
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| 引用本文： | 楼文珠,孙雪燕,李龙珠,宋梦婉,陶晶,郭俊明. 组蛋白脱乙酰酶抑制剂的抗癌作用[J]. 细胞生物学杂志, 2011, 0(9) |
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| 作者姓名： | 楼文珠 孙雪燕 李龙珠 宋梦婉 陶晶 郭俊明 |
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| 作者单位： | 宁波大学医学院生化室; |
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| 基金项目： | 浙江省新苗人才计划(No.200959); 宁波市自然科学基金(No.2010A610044)资助项目~~ |
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| 摘 要： | 组蛋白乙酰转移酶和组蛋白脱乙酰酶分别催化组蛋白的乙酰化和脱乙酰基反应,调节组蛋白的乙酰化水平,从而调控基因表达。这些过程与恶性肿瘤的发生具有密切的关系。组蛋白脱乙酰酶抑制剂通过增加细胞内组蛋白的乙酰化程度,调节多种基因的表达水平,抑制肿瘤细胞的增殖、诱导细胞分化和凋亡。该文从抑制细胞增殖、诱导细胞分化、诱导细胞凋亡和抗血管形成等4个方面介绍组蛋白脱乙酰酶抑制剂的抗癌机制,并简要介绍它们的分类。
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| 关 键 词： | 组蛋白脱乙酰酶抑制剂 肿瘤 抗癌作用 表观遗传 |
Anticancer Effects of Histone Deacetylase Inhibitors |
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| Lou Wenzhu,Sun Xueyan,Li Longzhu,Song Mengwan,Tao Jing,Guo Junming. Anticancer Effects of Histone Deacetylase Inhibitors[J]. Chinese Journal of Cell Biology, 2011, 0(9) |
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| Authors: | Lou Wenzhu Sun Xueyan Li Longzhu Song Mengwan Tao Jing Guo Junming |
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| Affiliation: | Lou Wenzhu,Sun Xueyan,Li Longzhu,Song Mengwan,Tao Jing,Guo Junming~* (Department of Biochemistry,School of Medicine,Ningbo University,Ningbo 315211,China) |
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| Abstract: | Histone acetyltransferase and histone deacetylase are enzymes that having opposite function. They modulate the level of acetylation of histone and regulate gene expression by addition or removal of acetyl groups to histone,respectively.They are associated with the occurrence of cancers.Recent researches found that by upregulating the level of histone acetylation and regulating the expression of target genes,histone deacetylase inhibitors inhibit proliferation,induce differentiation and apoptosis in tumor ce... |
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| Keywords: | histone deacetylase inhibitors tumor anticancer effect epigenetic |
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