| 诱导多功能干细胞的影响因素 |
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| 引用本文： | 汤黎娜,张杨,宋光启,施维,李子义. 诱导多功能干细胞的影响因素[J]. 细胞生物学杂志, 2011, 0(4) |
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| 作者姓名： | 汤黎娜 张杨 宋光启 施维 李子义 |
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| 作者单位： | 吉林大学畜牧兽医学院动物胚胎工程吉林省重点实验室;吉林大学分子酶学工程教育部重点实验室; |
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| 基金项目： | 国家重点基础研究发展规划(973计划,No.2009GB41000)资助项目~~ |
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| 摘 要： | 将体细胞诱导为多功能干细胞为人类的再生医学提供了一个全新的研究手段,从而可以不用损坏胚胎就能获得可用于治疗各种特殊疾病的细胞。本文比较了近年来关于生成诱导性多能干细胞(induced pluripotent stem cells,iPS细胞)的诱导方法及重编程效率,总结了这些方法的共同点;另外通过对每个不同试验过程的影响因素进行比较,归纳了影响iPS细胞重编程过程的几个因素。
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| 关 键 词： | 影响因素 诱导性多能干细胞(iPS) 重编程 效率 |
Impacting Factors for Induced Pluripotent Stem Cells |
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| Li-Na Tang,Yang Zhang,Guang-Qi Song,Wei Shi,Zi-Yi Li. Impacting Factors for Induced Pluripotent Stem Cells[J]. Chinese Journal of Cell Biology, 2011, 0(4) |
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| Authors: | Li-Na Tang Yang Zhang Guang-Qi Song Wei Shi Zi-Yi Li |
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| Affiliation: | Li-Na Tang~(1,2),Yang Zhang~1,Guang-Qi Song~1,Wei Shi~(2*),Zi-Yi Li~(1*) (1 Jilin Province Key Laboratory of Animal Embryo Engineering,College of Animal Science and Veterinary Medicine,Jilin University Changchun 130062,China,2 Key Laboratory for Molecular Enzymology and Engineering,the Ministry of Education,Jilin University Changchun 130032,China) |
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| Abstract: | Direct reprogramming of somatic cells to induced pluripotent stem cells(iPSCs) provides an invaluable resource for regenerative medicine,enabling the generation of patient-specific cells of any lineage without the use of embryonic material.We compared the currently reported protocols,identified the essential steps common to these methods,and summarized several factors that affect iPS cells reprogramming process,with an emphasis on standardization of certain parameters for accurate comparison between indepen... |
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| Keywords: | influential factor iPS reprogramming efficiency |
| 本文献已被 CNKI 等数据库收录！ |
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