Epstein-Barr virus-transformed B lymphocytes produce low molecular mass molecules with autocrine growth factor and competence factor activity |
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Authors: | Carlo Garzelli Agostino Bazzichi Addawe Mohamed Dayah Maria Manunta Marina Incaprera Giuseppe Falcone |
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Institution: | Department of Biomedicine, University of Pisa, Italy. |
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Abstract: | A human Epstein-Barr virus (EBV)-positive lymphoblastoid B cell line, named BA-D10-4, produces a factor of a molecular mass less than 10 kDa that promotes cell proliferation of both BA-D10-4 cells and other human T or B lymphoid cell lines, either EBV-positive or -negative. The factor synergizes with higher molecular mass autocrine growth factors and makes both BA-D10-4 cells and B cell lines from Burkitt's lymphoma, but not cells from T cell leukemia, more responsive to interleukin-1 and interleukin-6. Therefore, this low molecular mass factor seems to be an autocrine growth factor per se and to have the characteristics of a competence factor. |
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Keywords: | Epstein-Barr virus Cell transformation Growth factors |
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