Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus |
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| Authors: | Sara A. Sandstedt Priscilla K. Tucker |
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| Affiliation: | (1) Department of Ecology and Evolutionary Biology, and Museum of Zoology, University of Michigan, Ann Arbor, Michigan 48109, USA;(2) Present address: Department of Epidemiology, University of Michigan, 109 Observatory, Rm 2010 School of Public Health Building I, Ann Arbor, MI 48109, USA |
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| Abstract: | Two related genes with potentially similar functions, one on the Y chromosome and one on the X chromosome, were examined to determine if they evolved differently because of their chromosomal positions. Six hundred fifty-seven base pairs of coding sequence of Jarid1d (Smcy) on the Y chromosome and Jarid1c (Smcx) on the X chromosome were sequenced in 13 rodent taxa. An analysis of replacement and silent substitutions, using a counting method designed for samples with small evolutionary distances, showed a significant difference between the two genes. The different patterns of replacement and silent substitutions within Jarid1d and Jarid1c may be a result of evolutionary mechanisms that are particularly strong on the Y chromosome because of its unique properties. These findings are similar to results of previous studies of Y chromosomal genes in these and other mammalian taxa, suggesting that genes on the mammalian Y evolve in a chromosome-specific manner. |
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