Secretion of biologically active interferon-gamma inducible protein-10 (IP-10) by <Emphasis Type="Italic">Lactococcus lactis</Emphasis> |
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| Authors: | Julio Villatoro-Hernandez Maria J Loera-Arias Anali Gamez-Escobedo Moises Franco-Molina Jorge G Gomez-Gutierrez Humberto Rodriguez-Rocha Yolanda Gutierrez-Puente Odila Saucedo-Cardenas Jesus Valdes-Flores Roberto Montes-de-Oca-Luna |
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| Institution: | 1.Departamento de Histología,Facultad de Medicina, Universidad Autónoma de Nuevo León (UANL),Monterrey,México;2.Departamento de Microbiología e Inmunología,Facultad de Ciencias Biológicas, UANL,San Nicolás de los Garza,México;3.Departamento de Bioquímica,Facultad de Ciencias Biológicas, UANL,San Nicolás de los Garza,México;4.Departamento de Bioquímica,CINVESTAV,Apartado,México;5.División de Genética,Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social (IMSS),Monterrey,México |
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| Abstract: | Background Chemokines are a large group of chemotactic cytokines that regulate and direct migration of leukocytes, activate inflammatory
responses, and are involved in many other functions including regulation of tumor development. Interferon-gamma inducible-protein-10
(IP-10) is a member of the C-X-C subfamily of the chemokine family of cytokines. IP-10 specifically chemoattracts activated
T lymphocytes, monocytes, and NK cells. IP-10 has been described also as a modulator of other antitumor cytokines. These properties
make IP-10 a novel therapeutic molecule for the treatment of chronic and infectious diseases. Currently there are no suitable
live biological systems to produce and secrete IP-10. Lactococcus lactis has been well-characterized over the years as a safe microorganism to produce heterologous proteins and to be used as a safe,
live vaccine to deliver antigens and cytokines of interest. Here we report a recombinant strain of L. lactis genetically modified to produce and secrete biologically active IP-10. |
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