A Bayesian calibration model for combining different pre-processing methods in Affymetrix chips |
| |
Authors: | Marta Blangiardo Sylvia Richardson |
| |
Affiliation: | (1) Centre for Biostatistics, Imperial College, St. Mary's Campus, Norfolk Place, London, W2 1PG, UK |
| |
Abstract: | Background In gene expression studies a key role is played by the so called "pre-processing", a series of steps designed to extract the signal and account for the sources of variability due to the technology used rather than to biological differences between the RNA samples. At the moment there is no commonly agreed gold standard pre-processing method and each researcher has the responsibility to choose one method, incurring the risk of false positive and false negative features arising from the particular method chosen. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|