Disruption of Four Kinesin Genes in <Emphasis Type="Italic">Dictyostelium</Emphasis> |
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Authors: | Dilip K Nag Irina Tikhonenko Ikko Soga Michael P Koonce |
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Institution: | (1) Division of Molecular Medicine, Wadsworth Center, Albany, NY 12201-0509, USA;(2) Department of Biomedical Sciences, School of Public Health, University at Albany, Albany, NY 12201-0509, USA |
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Abstract: | Background Kinesin and dynein are the two families of microtubule-based motors that drive much of the intracellular movements in eukaryotic
cells. Using a gene knockout strategy, we address here the individual function(s) of four of the 13 kinesin proteins in Dictyostelium. The goal of our ongoing project is to establish a minimal motility proteome for this basal eukaryote, enabling us to contrast
motor functions here with the often far more elaborate motor families in the metazoans. |
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