Platypus globin genes and flanking loci suggest a new insertional model for beta-globin evolution in birds and mammals |
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| Authors: | Vidushi S Patel Steven JB Cooper Janine E Deakin Bob Fulton Tina Graves Wesley C Warren Richard K Wilson Jennifer AM Graves |
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| Affiliation: | (1) The ARC Centre for Kangaroo Genomics, Research School of Biological Sciences, The Australian National University, Canberra, ACT, 2601, Australia;(2) Australian Centre for Evolutionary Biology and Biodiversity, The University of Adelaide, Adelaide, SA, 5005, Australia;(3) Evolutionary Biology Unit, South Australian Museu, Adelaide, SA, 5005, Australia;(4) Genome Sequencing Center, Washington University School of Medicine, St Louis, Missouri 63108, USA |
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| Abstract: | Background Vertebrate alpha (α)- and beta (β)-globin gene families exemplify the way in which genomes evolve to produce functional complexity. From tandem duplication of a single globin locus, the α- and β-globin clusters expanded, and then were separated onto different chromosomes. The previous finding of a fossil β-globin gene (ω) in the marsupial α-cluster, however, suggested that duplication of the α-β cluster onto two chromosomes, followed by lineage-specific gene loss and duplication, produced paralogous α- and β-globin clusters in birds and mammals. Here we analyse genomic data from an egg-laying monotreme mammal, the platypus (Ornithorhynchus anatinus), to explore haemoglobin evolution at the stem of the mammalian radiation. |
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